Isoamyl alcohol 3-Methyl-1-butanol is a colorless liquid with the molecular formula C5H
12O, especially (H3C–)2CH–CH2–CH2–OH. It is one of several isomers of pentanol (amyl alcohol). It is also known as isoamyl alcohol, isoamyl alcohol, or (in the IUPAC recommended nomenclature) 3-methyl-butan-1-ol. Its old name was isobutyl carbinol.
Isoamyl alcohol 3-Methyl-1-butanol is an ingredient in the production of banana oil, an ester found in nature and also produced industrially as a flavoring agent. It is a common fusel alcohol that is a major by-product of ethanol fermentation.
3-Methyl-1-butanol is used as an active ingredient and Kovac reagent in banana oil production. It is used as a defoamer. Used as an intermediate in the manufacture of corrosion inhibitors, buoyancy aids, fuel and lubricating oil additives, PVC stabilizers, medicines, cosmetics, plasticizers, rubber additives and paint solvents.
Isoamyl alcohol (3-methyl-1-butanol) is a clear, colorless alcohol with the molecular formula C5H12O. It is one of several isomers of pentanol.
3-Methyl-1-butanol (MEB) and 2-methyl-1-propanol (MEP) were tested for their prenatal inhalation toxicity in pregnant Wistar rats or Himalayan rabbits. Twenty-five female rats and 15 female rabbits per group were exposed to MEB and MEP vapors at concentrations of 10, 2.5, or 0.5 mg/liter, 6 hr/day. The rats were exposed on Days 6–15 postcoitum (pc) and the rabbits were exposed on Days 7–19 postinsemination (pi). Control groups were exposed to clean air. The body weights of the animals of either species were determined several times throughout the studies. All rats and all rabbits were killed on Day 20 pc and Day 29 pi, respectively. The fetuses were removed from the uterus and examined for compound-related effects. The high concentration of 10 mg/liter caused a slight retardation of body weight gain in the dams of either species exposed to MEB and in the dams of rabbits exposed to MEP during the first days of the exposure period. Eye irritation was observed only in the MEB-treated rabbits during the period of exposure to 10 mg/liter. The fetuses of either species exhibited no signs of embryo-/fetotoxicity or teratogenic effects caused by MEP or MEB. Under the experimental conditions, 2.5 mg/liter was found to be a no-observable-adverse-effect level (NOAEL) for the dams of either species exposed to MEB and for the does exposed to MEP, whereas 10 mg/liter MEP was the NOAEL for the maternal rats. For both substances 10 mg/liter was defined as the NOAEL for the conceptuses of either species.
Isoamyl alcohol, also known as isoamyl alcohol or 3-methylbutanol, belongs to the primary alcohol class of organic compounds. Primary alcohols are compounds containing primary alcohol functional groups with the general structure RCOH (R = alkyl, aryl). Therefore, isoamyl alcohol is considered a fatty alcohol. Isoamyl alcohol is present in all eukaryotic organisms, from yeast to plants to humans. In yeast, isoamyl alcohol is involved in a metabolic pathway known as the leucine degradation pathway. According to the literature review, a large number of articles have been published on isoamyl alcohol.