Interactions of Levodopa

Drug interactions may change the way your medications work or increase your risk of serious side effects. This document does not cover all possible drug interactions. Keep a list of all products you use (including prescription/over-the-counter and herbal products) and share it with your doctor and pharmacist. Do not start, stop or change the dosage of any medication without your doctor’s approval.


Some products that may interact with levodopa include antipsychotic drugs (e.g., chlorpromazine, haloperidol, thiolidazine), and certain drugs used to treat hypertension (e.g., methyldopa).


Taking MAO inhibitors with this drug can lead to serious (and potentially fatal) drug interactions. Avoid MAO inhibitors (isophorazid, linezolid, methadone, methylene blue, moclobeamide, phenylehydrazine, procarbazid, cyclopropylamine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this drug. However, certain MAO inhibitors (resagiline, salfiamide, selegiline) may be used under the careful supervision of a physician. Ask your doctor when to start or stop taking this medication.


This drug may interfere with certain laboratory tests (including urinary catecholamine/glucose/ketone tests) and may result in incorrect test results. Make sure lab staff and all of your doctors are aware of your use of this medication.


Too much

If someone overdoses and develops serious symptoms, such as fainting or difficulty breathing, call 911. Otherwise, call poison Control immediately. Residents of the United States can call their local poison control center at 1-800-222-1222. Canadian residents can call the provincial poison control Center. Symptoms of an overdose may include severe dizziness, irregular heartbeat, and mental/emotional changes (such as agitation).



Don’t give the medicine to anyone else.


Regular laboratory and/or medical tests (e.g. heart/kidney/liver function, CBC) should be performed to monitor your progress or check for side effects. Consult your doctor for more details.


Missed dose

If you miss the dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take the next dose regularly. Do not double the dose to catch up.

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